BREAST CANCER TREATMENT IN THE ERA OF PRECISION MEDICINE

Breast Cancer Treatment in the Era of Precision Medicine

Breast cancer is the most common cancer in women in the Western world.Treatment decisions in the adjuvant and metastatic setting are based on three immunohistochemistry markers, namely estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2).Based on the St.Gallen consensus, four distinct subtypes are

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The mitochondrial disease associated protein Ndufaf2 is dispensable for Complex-1 assembly but critical for the regulation of oxidative stress

Deficiency in human mitochondrial Complex-1 has been linked to a wide variety of neurological disorders.Homozygous deletion of the Complex-1 associated protein, Ndufaf2, leads to a severe juvenile onset encephalopathy involving degeneration of the substantia nigra and other sub-cortical regions resulting in adolescent lethality.To understand the pr

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Is Asking Questions on Rounds a Teachable Skill? A Randomized Controlled Trial to Increase Attendings’ Asking Questions

Helen M Shields,1 James P Honan,2 Jeffrey D Goldsmith,3,* Rachna Madan,4,* Stephen R Pelletier,5 Christopher L Roy,6 Lindsey C Wu6 1Division of Medical Communications and Division of Gastroenterology, Hepatology and Endoscopy, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA; 2Harvard Graduate School of Education, Camb

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